The Criminal Division conducts all of the office's criminal investigations and prosecutions and advises the United States Attorney on criminal law related matters. The Criminal Division collaborates with other Department of Justice agencies concerning criminal cases and often serves as a contact between the U.S. Attorney's Office and other law enforcement agencies on federal, state, and local levels. There are approximately 83 Assistant U.S. Attorneys who work in the Criminal Division, which consists of the following nine units:
|Appeals Unit||Cybercrime Unit||Economic Crimes Unit|
|Health Care Fraud Unit||Major Crimes Unit||Narcotics and Money Laundering|
|National Security Unit||Organized Crime and Gang Unit||Public Corruption Unit|
The Civil Division represents the United States and its departments, agencies, and employees in civil cases filed in Massachusetts in both the trial and appeals courts. There are approximately 18 Assistant U.S. Attorneys who work in the Civil Division, which consists of the following five units:
|Affirmative Civil Enforcement||Asset Forfeiture Unit||Civil Rights Unit||Defensive Litigation||Financial Litigation Unit|
The Administrative Division provides critical administrative services to the employees and programs of the United States Attorney's Office. It includes the Administrative Officer, who is the principal advisor to the U.S. Attorney on administration, and employs 26 staff members and seven stay-in-school students. The Administrative Division specializes in Personnel Management & Human Resources, Systems and Information Management, Financial Management, and Support Services.