Alleged Sinaloa Cartel Methamphetamine Trafficker Extradited from Mexico

SAN DIEGO – Marco Antonio Lopez-Guerrero, an alleged Mexicali-based methamphetamine trafficker linked to the Sinaloa Cartel, was extradited from Mexico on October 24th to face drug and firearms charges.

Lopez-Guerrero was indicted by a federal grand jury in the Southern District of California in July 2020.  He is charged with Conspiracy to Import Methamphetamine; Conspiracy to Distribute Methamphetamine; Attempted Export of Defense Articles Without a License; and Smuggling Goods (i.e., firearms and ammunition) from the United States to Mexico.

According to court records, Lopez-Guerrero used young girls to smuggle methamphetamine through pedestrian lanes of Southern California ports of entry and to distribute the drugs in San Diego, San Bernardino and elsewhere. Lopez-Guerrero also used an ultra-light aircraft to smuggle methamphetamine; and he smuggled weapons to Mexico, including at least one short-barrel AR-15 rifle without a serial number and more than 150 rounds of ammunition, court records indicate.

At his first appearance in federal court on October 27th, Lopez-Guerrero was arraigned and entered a not-guilty plea before U.S. Magistrate Judge Karen S. Crawford. Following a detention hearing on October 30, 2025, Lopez-Guerrero was ordered detained pending trial. His next court appearance is scheduled for November 21, 2025, for a motion hearing/trial setting before U.S. District Judge Jinsook Ohta.  

The prosecution in this case is part of a multi-year investigation that resulted in the seizure of more than 180 kilograms of methamphetamine; 19 kilograms of fentanyl; 2 kilograms of heroin; along with firearms and ammunition.

The Justice Department’s Office of International Affairs provided significant assistance in securing the defendant’s arrest and extradition from Mexico. The U.S. Marshals Service assisted in bringing the defendant to the United States. The case is being prosecuted by Assistant U.S. Attorneys Lawrence A. Casper and Edward Chang.

DEFENDANT                                               Case Number 20cr2054-JO                                     

Marco Antonio Lopez-Guerrero                                             Age: 34           Mexicali, MX

SUMMARY OF CHARGES

Conspiracy to Import Methamphetamine, in violation of Title 21, U.S.C. Sections 952, 960 and 963.

Maximum Penalty:  Mandatory minimum 10 years and up to life in prison, $10 million fine.

Conspiracy to Distribute Methamphetamine, in violation of Title 21, U.S.C. Sections 841, 846. Maximum Penalty: Mandatory minimum 10 years and up to life in prison, $10 million fine.

Attempted Export of Defense Articles Without a License in violation of Title 22, U.S.C. Section 2778.

Maximum Penalty:  Twenty years in prison, $1 million fine.

Smuggling of goods in violation of Title 18, U.S.C. Section 554

Maximum Penalty: Ten years in prison, $250,000 fine.

INVESTIGATING AGENCIES

Drug Enforcement Administration

Homeland Security Investigations

Imperial County Sheriff’s Department

U.S. Border Patrol – El Centro Sector

Department of Justice, Organized Crime Drug Enforcement Task Force

Department of Justice, Office of International Affairs

San Diego/Imperial County High Intensity Drug Trafficking Area program

*The charges and allegations contained in an indictment or complaint are merely accusations, and the defendants are considered innocent unless and until proven guilty.

This case is part of the Homeland Security Task Force (HSTF) initiative established by Executive Order 14159, Protecting the American People Against Invasion. The HSTF is a whole-of-government partnership dedicated to eliminating criminal cartels, foreign gangs, transnational criminal organizations, and human smuggling and trafficking rings operating in the United States and abroad. Through historic interagency collaboration, the HSTF directs the full might of United States law enforcement towards identifying, investigating, and prosecuting the full spectrum of crimes committed by these organizations, which have long fueled violence and instability within our borders. In performing this work, the HSTF places special emphasis on investigating and prosecuting those engaged in child trafficking or other crimes involving children. The HSTF further utilizes all available tools to prosecute and remove the most violent criminal aliens from the United States. HSTF San Diego comprises agents and officers from FBI, Homeland Security Investigations, DEA, ATF, U.S. Marshals, Department of Defense, U.S. Postal Inspection Service, Naval Criminal Investigative Service, IRS Criminal Investigation, U.S. Coast Guard, U.S. Customs and Border Protection and Interpol, with the prosecution being led by the United States Attorney’s Office for the Southern District of California.